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Afatinib BIBW2992 Intermediate4

Catalog No.: R10300
CAS No.: 314771-76-1
Formula: C18H16N4O2FCl
Weight: 374.79664
Details:
Theoretical analysis

CAS NO.:314771-76-1

Molecular Formula:C18H16N4O2FCl

Molecular Weight:374.79664

Description
Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
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Quality control data

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