Cabozantinib S-malate (XL184 S-malate; BMS-907351 S-malate)

CAS NO.:1140909-48-3

Molecular Formula:C₃₂H₃₀FN₃O₁₀

Molecular Weight:635.6

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

abozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively.

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Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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