D4476 (Synonyms: Casein Kinase I Inhibitor)

CAS NO.:301836-43-1

Molecular Formula:C₂₃H₁₈N₄O₃

Molecular Weight:398.41402

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.

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