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PTC124
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Details:
Theoretical analysis
CAS NO.:775304-57-9
Molecular Formula:C15H9N2O3F
Molecular Weight:284.24196
Purity: > 98%
Solubility (R.T.: 25℃): DMSO
Stability: - 20℃ 2 years
Description
Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation). Phase 3.
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Quality control data
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
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