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LY3039478;Crenigacestat

Catalog No.: R10954
CAS No.: 1421438-81-4
Formula: C22H23F3N4O4
Weight: 464.438
Details:
Theoretical analysis

CAS NO.:1421438-81-4

Molecular Formula:C22H23F3N4O4

Molecular Weight:464.438

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Description
LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited expression of Notch-regulated genes and N1ICD cleavage in the tumor microenvironment.
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Quality control data

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

Product will be shipped with supporting analytical data.

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