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JH-II-127
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Details:
Theoretical analysis
CAS NO.:1700693-08-8
Molecular Formula:C19H21ClN6O3
Molecular Weight:416.861442327499
Purity: > 98%
Solubility (R.T.: 25℃): DMSO
Stability: - 20℃ 2 years
Description
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T. IC50 value: 2.2 n(LRRK2-G2019S), 6.6 nM(LRRK2-wild-type), 47.7 nM (LRRK2-A2016T) Target: LRRK2 JH-II-127 is a potent and selective inhibitor of both wild-type and G2019S mutant LRRK2. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg.
Molecular Weight:416.86
Formula:C₁₉H₂₁ClN₆O₃
Molecular Weight:416.86
Formula:C₁₉H₂₁ClN₆O₃
Availability and price
Packing: 10mg/50mg/100mg/500mg/1g and we provide a variety of packaging.
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Quality control data
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
Product will be shipped with supporting analytical data.
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