IOWH032

CAS NO.:1191252-49-9

Molecular Formula:C₂₂H₁₅N₃O₄Br₂

Molecular Weight:545.1802

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

IOWH-032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays. IC50 value: 1.01 uM (CHO-CFTR FLIPR)  Target: CFTR Profiling of iOWH032 showed it to be a CFTR inhibitor in T84 and CHO-CFTR cell based assays. It also demonstrated statistical significant inhibition at both 100 g & 10 g doses in the mouse closed-loop model. iOWH032 was further profiled in a cecetomized rat model. iOWH032 reduced the fecal output index by ~70%, compared to vehicle (cholera toxin), up to 8 hours after a single 5 mg/kg po dose. 

Packing: 10mg/50mg/100mg/500mg/1g and we provide a variety of packaging.

We offer significant discount for larger quantity order.

For quotation, question, and order, please send email to sales@rechemscience.com

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

Product will be shipped with supporting analytical data.

Fast delivery about 4-5 working days.