Vactosertib (Synonyms: EW-7197; TEW-7197)

CAS NO.:1352608-82-2

Molecular Formula:C₂₂H₁₈FN₇

Molecular Weight:399.423626422882

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect.

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