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APY29
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Details:
Theoretical analysis
CAS NO.:1216665-49-4
Molecular Formula:C₁₇H₁₆N₈
Molecular Weight:332.36
Purity: > 98%
Solubility (R.T.: 25℃): DMSO
Stability: - 20℃ 2 years
Description
APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM. APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain.
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Quality control data
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
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