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IWP-2

Catalog No.: R11830
CAS No.: 686770-61-6
Formula: C22H18N4O2S3
Weight: 466.598920345306
Details:
Theoretical analysis

CAS NO.:686770-61-6

Molecular Formula:C22H18N4O2S3

Molecular Weight:466.598920345306

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Description
IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ.
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Quality control data

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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