TPX-0005

CAS NO.:1802220-02-5

Molecular Formula:C₁₈H₁₈FN₅O₂

Molecular Weight:355.37

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Repotrectinib (TPX-0005) is a potent ROS1 (IC₅₀=0.07 nM), TRK (0.83/0.05/0.1 nM=TRKA/B/C) inhibitor. Repotrectinib (TPX-0005) potently inhibits WT ALK (1.01 nM) and mutant ALKs including ALK G1202R (1.26 nM) and ALK L1196M (1.08 nM). It also inhibits a variety of other kinases, including JAK2, LYN, Src, and FAK (1.04, 1.66, 5.3, and 6.96 nM, respectively).
 

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