MELK-T1(JNJ-47117096)

CAS NO.:1610586-62-3

Molecular Formula:C₂₁H₂₂N₄O₂

Molecular Weight:362.424984455109

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

MELK-T1 is a potent and selective inhibitor of protein kinase MELK. MELK-T1 decreases DNA-damage tolerance in proliferating cancer cells. MELK-T1 triggered a rapid and proteasome-dependent degradation of the MELK protein. Treatment of MCF-7 breast adenocarcinoma cells with MELK-T1 induced the accumulation of stalled replication forks and double-strand breaks that culminated in a replicative senescence phenotype. MELK-T1 induced a strong phosphorylation of p53, a prolonged upregulation of p21 and a downregulation of FOXM1 target genes.

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