SB 203580 hydrochloride (RWJ 64809 hydrochloride)

CAS NO.:869185-85-3

Molecular Formula:C₂₁H₁₇ClFN₃Os

Molecular Weight:413.895585775375

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

SB 203580 hydrochloride (RWJ 64809 hydrochloride) is a widely used p38 MAPK inhibitor. SB 203580 hydrochloride (RWJ 64809 hydrochloride) inhibits SAPK2a/p38 and SAPK2b/p38β2, with IC50s of 50 nM and 500 nM, respectively. LCK, GSK3β and PKBα are also inhibited by SB 203580 hydrochloride (RWJ 64809 hydrochloride), but the IC50s are 100-500-fold higher than that for SAPK2a/p38.

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