Olodanrigan (Synonyms: EMA401; PD-126055)

CAS NO.:1316755-16-4

Molecular Formula:C₃₂H₂₉NO₅

Molecular Weight:507.576369047165

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Olodanrigan (EMA401; PD-126055), a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401; PD-126055) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. 

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