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jnd3229
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Details:
Theoretical analysis
CAS NO.:2260886-64-2
Molecular Formula:C33H41ClN8O2
Molecular Weight:617.18
Purity: > 98%
Solubility (R.T.: 25℃): DMSO
Stability: - 20℃ 2 years
Description
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM). JND3229 potently inhibited EGFRC797S mutated kinase and strongly suppressed the proliferation of BaF3 cells harboring the EGFRL858R/T790M/C797S and EGFR19D/T790M/C797S mutations with IC50 values of 0.51 and 0.32 μM, respectively.
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Quality control data
Quality Control by H-NMR,C-NMR,LC-MS,HPLC.
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