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LUF6000

Catalog No.: R2030081
CAS No.: 890087-21-5
Formula: C22H20Cl2N4
Weight: 411.32700252533
Details:
Theoretical analysis

CAS NO.:890087-21-5

Molecular Formula:C22H20Cl2N4

Molecular Weight:411.32700252533

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Description
LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). IC50 value: Target: A3 adenosine receptor LUF6000 was found to be an allosteric enhancer of Emax of structurally diverse agonists at the A3 AR, being more effective for low-Emax agonists than for high-Emax agonists. LUF6000 exerted an Emax-enhancing effect at a concentration of 0.1 microM or higher, and was shown to increase the Emax of Cl-IB-MECA and other low-efficacy agonists to a larger extent than that of the high-efficacy agonist NECA. Interestingly, LUF6000 converted a nucleoside A3 AR antagonist MRS542, but not a non-nucleoside antagonist MRS1220, into an agonist. 
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Packing: 10mg/50mg/100mg/500mg/1g and we provide a variety of packaging.

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Quality control data

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

Product will be shipped with supporting analytical data.

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