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YL0919 hydrochloride;YL-0919hydrochloride

Catalog No.: R2030154
CAS No.: 1339058-04-6
Formula: C18H23ClN2O2
Weight: 334.840423822403
Details:
Theoretical analysis

CAS NO.:1339058-04-6

Molecular Formula:C18H23ClN2O2

Molecular Weight:334.840423822403

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Description
YL0919, a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor,the IC50 values of YL-0919 inhibiting the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells were 1.78±0.34 nM and 1.93±0.18 nM respectively. target: 5-HT1A receptor IC50:1.78±0.34 nM(rat cerebral cortical synaptosomes) IC50:1.93±0.18 nM(human recombinant cells)" In vivo: WAY-100635 completely antagonized the antidepressant-like activity of YL-0919 in both behavioral models, suggesting that activation of the 5-HT1A receptor is critical in the antidepressant-like effect of YL-0919. The administered dose of WAY-100635 ranged from 0.1–0.3 mg/kg, which reportedly has no effect on locomotor activity and only blocks the activation of 5-HT1A receptor.
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Quality control data

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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