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GDC0623;GDC-0623;RG 7421;MEK inhibitor 1
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Details:
Theoretical analysis
CAS NO.:1168091-68-6
Molecular Formula:C₁₆H₁₄FIn₄O₃
Molecular Weight:456.21
Purity: > 98%
Solubility (R.T.: 25℃): DMSO
Stability: - 20℃ 2 years
Description
GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).
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Quality control data
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