Nolatrexed dihydrochloride(AG-337 dihydrochloride)

CAS NO.:152946-68-4

Molecular Formula:C₁₄H₁₄Cl₂N₄Os

Molecular Weight:357.26

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase.Nolatrexed dihydrochloride (AG 337) has a

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