KPT185

CAS NO.:1333151-73-7

Molecular Formula:C₁₆H₁₆F₃N₃O₃

Molecular Weight:355.31

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations (IC50=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and p

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