Plinabulin(NPI-2358)

CAS NO.:714272-27-2

Molecular Formula:C₁₉H₂₀N₄O₂

Molecular Weight:336.39

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells.Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cell

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