GSK-J4

CAS NO.:1373423-53-0

Molecular Formula:C₂₄H₂₇N₅O₂

Molecular Weight:417.5

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively.GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM.GSK J4 is a cell permeable p

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