SAR405

CAS NO.:1523406-39-4

Molecular Formula:C₁₉H₂₁ClF₃N₅O₂

Molecular Weight:443.85

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM).SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition.Anticancer activity.

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