XAV939

CAS NO.:284028-89-3

Molecular Formula:C₁₄H₁₁F₃N₂Os

Molecular Weight:312.31

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

XAV-939 is a Wnt/β-catenin pathway inhibitor.XAV-939 stabilizes axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2 (IC50s of 5 and 2 nM,respectively), thereby stimulating β-catenin degradation.XAV939 binds tightly to the cata

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