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Gefitinib-based PROTAC 3
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Details:
Theoretical analysis
CAS NO.:2230821-27-7
Molecular Formula:C₄₇H₅₇ClFN₇O₈S
Molecular Weight:934.51
Purity: > 98%
Solubility (R.T.: 25℃): DMSO
Stability: - 20℃ 2 years
Description
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.
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