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TH 5487

Catalog No.: R2053338
CAS No.: 2304947-71-3
Formula: C₁₉H₁₈BrIn₄O₂
Weight: 541.18
Details:
Theoretical analysis

CAS NO.:2304947-71-3

Molecular Formula:C₁₉H₁₈BrIn₄O₂

Molecular Weight:541.18

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Description
TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.
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