BMS986165

CAS NO.:1609392-27-9

Molecular Formula:C₂₀H₁₉D₃N₈O₃

Molecular Weight:425.46

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases, which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain. BMS-986165 inhibits IL-12/23 and type I IFN pathways.

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Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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