DT2216

CAS NO.:2365172-42-3

Molecular Formula:C₇₇H₉₆ClF₃N₁₀O₁₀S₄

Molecular Weight:1542.36

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

DT2216 is a potent and selective BCL-XL degrader based on PROTAC technology. SIAIS178 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets.

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