MRTX1257

CAS NO.:2206736-04-9

Molecular Formula:C₃₃H₃₉N₇O₂

Molecular Weight:565.71

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.MRTX1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above the

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