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E7449

Catalog No.: R21082371
CAS No.: 1140964-99-3
Formula: C18H15N5O
Weight: 317.345
Details:
Theoretical analysis

CAS NO.:1140964-99-3

Molecular Formula:C18H15N5O

Molecular Weight:317.345

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Description
E7449 is an effective inhibitor of PARP1 and PARP2, and can inhibit the activity of TNKS1 and TNKS2. In the experiment with 32p-NAD + as the substrate, the IC50 values for PARP1, PARP2, TNKS1 and TNKS2 were 2.0, respectively. 1.0, ~ 50 and ~ 50 nM.
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Quality control data

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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