CU-CPT-8m

CAS NO.:125079-83-6

Molecular Formula:C₁₄H₁₂N₄O

Molecular Weight:252.28

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

CU-CPT8m is a Toll-like receptor 8 (TLR8) specific small-molecule inhibitor that exerts “potent anti-inflammatory effects” on the tissue of patients with arthritis, osteoarthritis and Still’s disease, a rare autoimmune illness. CU-CPT8m has a Kd of 220 nM and IC50 of 67 nM, with negligible cytotoxicity; shows no effect on TLR1/2/6, TLR3, TLR4, TLR5, TLR7 and TLR9; inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells with IC50 of 90 nM, also abolishes the elevation of TNF-α and IL-8 mRNA levels; suppresses the proinflammatory cytokine production in multiple human primary cells derived from different patients.

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