BRD-K98645985

CAS NO.:1357647-78-9

Molecular Formula:C₃₃H₄₃N₅O₄

Molecular Weight:573.73

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Brd-k98645985 is a class of 12 yuan macrocyclic lactam and is also an inhibitor of BAF (Brg/Brahma-associated factors) transcriptional repression, with EC50 of ~2.37 µM. Brd-k98645985 binds to ARID1A specific BAF complex to prevent nucleosome localization and effectively reverse HIV-1 latency without T cell toxicity.

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