SOMG-833

CAS NO.:1268264-10-3

Molecular Formula:C₂₂H₂₂F₃N₅O₂

Molecular Weight:445.446

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

A potent, selective ATP-competitive C-Met inhibitor with an IC50 of 0.93 nM; Showed > 10,000-fold selectivity for 20 kinase groups, including RON, a member of the C-Met family, and AXL, a highly homologous kinase; Significantly inhibited c-Met phosphorylation and c-MEt-dependent proliferation of EBC-1, MSNn-45, SNU-5 and BaF3/TPR-MET cell lines, IC50 stagnated through G1/S cell cycle, 0.160-0.457μM; It showed remarkable anti-tumor effect in vivo.

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