KH-CB19

CAS NO.:1354037-26-5

Molecular Formula:C₁₅H₁₃Cl₂N₃O₂

Molecular Weight:338.19

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

KH-CB19 is a potent and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4). IC50 value: 20 nM (CLK1) Target: CLK1/4 inhibitor in vitro: KH-CB19 showed potent inhibition of CLK1 with an IC50 of 20 nM, and for the pure isomer KH-CB19, almost 100-fold selectivity against the CLK3 isoform. Pretreatment of cells with KH-CB19 or TG003 led to a reduction of the TNF-α-induced increase in phosphorylation of all analyzed SR proteins compared with TNF-α-stimulated controls.Treatment of resting cells with 10 μM KH-CB19 significantly reduced the basal expression of flTF as well as asHTF .

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