KDOAM-25

CAS NO.:2230731-99-2

Molecular Formula:C₁₅H₂₅N₅O₂

Molecular Weight:307.39

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

KDOAM-25 is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells.

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Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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