TM2-115

CAS NO.:1197196-47-6

Molecular Formula:C₂₉H₃₉N₅O₂

Molecular Weight:489.664

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Inhibition of histone methyltransferase biX-01294 derivatives of malaria parasites, leading to rapid and irreversible parasite death; The IC50 of the cultured PLASmodium falciparum 3D7 parasite was 100 nM, which was 22 times more potent than IC50 against two human cell lines and one mouse cell line. During treatment of P. falciparum parasites, histone H3K4me3 levels were significantly reduced in a concentration-dependent and time-dependent manner.

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