NecroX-7

CAS NO.:1120333-38-1

Molecular Formula:C₂₄H₂₉N₃O₃S

Molecular Weight:516.676

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Necrox-7 is a small molecule necrosis regulator and potent antioxidant molecule that binds to certain types of free radicals, especially NAPQI; By inhibiting NF-κB activity and C-FOS expression, osteoclast differentiation was inhibited and liver necrosis secondary to IR injury was reduced. In the body. Reduced cell death and ROS/RNS formation in T-BHP - and APAP-induced HepG2 human hepatocarcinoma and primary mouse hepatocytes, and also protected mice from APAP-induced liver injury and mortality by directly binding NAPQI.

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