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PF3644022

Catalog No.: R2202112
CAS No.: 1276121-88-0
Formula: C21H18N4Os
Weight: 374.46
Details:
Theoretical analysis

CAS NO.:1276121-88-0

Molecular Formula:C21H18N4Os

Molecular Weight:374.46

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Description
PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect.
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Quality control data

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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