DT-061

CAS NO.:1809427-18-6

Molecular Formula:C₂₅H₂₃F₃N₂O₅S

Molecular Weight:520.52073597908

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

SMAP(DT-061,DT061) is an oral bioavailable small molecule activator of PP2A that inhibits KRAS-driven tumor growth. It acts by binding to the PP2A-α scaffold subunit to drive the conformational change of PP2A. Inhibit the growth of KRAS mutant lung cancer. Mouse xenograft and transgenic models.

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