Zotatifin (eFT226)

CAS NO.:2098191-53-6

Molecular Formula:C₂₈H₂₉N₃O₅

Molecular Weight:487.55

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex[1]. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM).

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