BIX HCl

CAS NO.:1422252-46-7

Molecular Formula:C₁₆H₂₀ClF₃N₄O₂

Molecular Weight:392.8

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. It displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. It shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury.

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