NGB 2904 hydrochloride

CAS NO.:189061-11-8

Molecular Formula:C₂₈H₃₀Cl₃N₃O

Molecular Weight:530.92

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

NGB 2904 hydrochloride is a potent, selective, orally active and brain-penetrated antagonist of dopamine D3 receptor, with a Ki of 1.4 nM. It shows selectivity for D3 over D2, 5-HT2, α1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). It antagonizes Quinpirole-stimulated mitogenesis.

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