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AS-99

Catalog No.: R240402206
CAS No.: 2323623-93-2
Formula: C27H30F3N5O3S2
Weight: 593.68
Details:
Theoretical analysis

CAS NO.:2323623-93-2

Molecular Formula:C27H30F3N5O3S2

Molecular Weight:593.68

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

Description
AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. It blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo.
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Quality control data

Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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