JNJ-63576253

CAS NO.:2110428-64-1

Molecular Formula:C₂₃H₂₂ClF₃N₆O₂S

Molecular Weight:538.972992420197

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).

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