HKI272; HKI272; Neratinib Intermediate1

CAS NO.:524955-09-7

Molecular Formula:C₁₂H₁₁N₂OCl

Molecular Weight:234.68154

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.

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