HKI272; HKI272; Neratinib Intermediate2

CAS NO.:848133-76-6

Molecular Formula:C₁₄H₁₂N₃O₂Cl

Molecular Weight:289.71698

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.

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