L685458

CAS NO.:292632-98-5

Molecular Formula:C₃₉H₅₂N₄O₆

Molecular Weight:672.85338

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

L-685458 is a potent inhibitor of Amyloid β-Protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. IC50 value: 17 nM Target: γ-secretase in vitro: L-685458 is a Notch inhibitor. L-685458 blocks Notch activation in the two cell lines in terms of reduced cytoplasmic distribution and almost diminished nuclear labelling of Hes1 proteins.  L-685458 is a γ-secretase inhibitor.

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