JH-RE-06

CAS NO.:1361227-90-8

Molecular Formula:C₂₀H₁₆Cl₃N₃O₄

Molecular Weight:468.72

Purity: > 98%

Solubility (R.T.: 25℃): DMSO

Stability: - 20℃ 2 years

JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. It disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy.

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Quality Control by H-NMR,C-NMR,LC-MS,HPLC.

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